Diabetes mellitus and covid 19. A Covid és a diabetes mellitus | woma-dugulaselharitas.hu


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There is a lack of evidence-based targeted pharmacological therapy for its prevention and treatment. We aim to compare the effects of a World Health Organization recommendation-based education and a personalised complex preventive lifestyle intervention package based on the same WHO recommendation on the outcomes of the COVID Hungarian population over the age of 60 years without confirmed COVID will be approached to participate in a telephone health assessment and lifestyle counselling voluntarily.

Volunteers will be randomised into two groups: A general health education and B personalised health education. Participants will go through questioning and recommendation in 5 fields: 1 mental health, 2 smoking habits, 3 physical activity, 4 dietary habits, and 5 alcohol consumption.

A Covid és a diabetes mellitus | woma-dugulaselharitas.hu

Both groups A and B will receive the same line of questioning to assess habits concerning these topics. Assessment will be done weekly during the first month, every second week in the second month, then monthly.

The estimated sample size is subjects per study arm. The planned duration of the follow-up is a minimum of 1 year. Consequently, lifestyle changes can reduce the incidence of life-threatening conditions and attenuate the detrimental effects of the pandemic seriously affecting the older population.

DOI: Euglycemic diabetic ketoacidosis eu-DKA is a rare life-threatening complication associated with the use of SGLT2 inhibitor that may be unnoticed, particularly in a pandemic setting, due to the absence of significant hyperglycemia, delaying its treatment. In this report, we describe a case of a year-old patient who presented an elevated anion gap metabolic acidosis during a SARS-CoV-2 infection and was diagnosed with SGLT2-associated euglycemic diabetic ketoacidosis.

At the time of writing this study protocol, there are more thanconfirmed cases with 37, fatalities across countries, according to the Center For Systems Science and Engineering CSSE at Johns Hopkins University, including cases and 15 deaths in Hungary. The tendency predicts that the epidemic is far from its peak [ 2 ]. As often seen in the case of other epidemics, most cases can be asymptomatic or develop only mild symptoms and remain undiagnosed.

Therefore, it is difficult to estimate the true incidence and the disease outcomes precisely [ 34 ]. These numbers are comparable to the outcomes of earlier coronavirus epidemics [ 910 ] and more severe than H1N1 pandemics in [ 11 ].

Hivatkozások évente

Significant efforts have been invested in research and development to re-target existing and discover new pharmacological treatments and preventive strategies against COVID [ 12 ], as indicated by the number of submitted protocols of the currently recruiting randomised trials on ClinicalTrials. Nevertheless, it must be noted that we lack evidence-based targeted pharmacological therapy for prevention and treatment alike [ 13 ].

None of the registered studies investigates the effects of lifestyle interventions in the prevention of poor outcomes in the COVID epidemic. Advanced age and pre-existing comorbidities, such as cancer, cardiovascular disease, or diabetes mellitus, predispose to a more severe disease course and ICU admission [ 6141516 ].

The high risk of being infected with COVID as well as the social distancing and quarantining as primary recommendations for the suppression of virus transmission may generate a high level of anxiety and mental stress [ 1718 ].

In infected patients, better mental health might even have a positive impact on disease progression and survival [ 1920 ]. Therefore, efforts for better coping with the aversive psychological states caused by the COVID outbreak have high importance in mental health resilience.

The role of lifestyle factors and fitness in the severity of COVID has remained unexplored except for two recent studies. The latter seemingly contradicts the results of a very recent registry analysis of almostparticipants where higher body mass index indirectly, better nutritional status proved to be neutral or even preventive although against non-COVID upper airway infections [ 23 ].

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These suggest that personalised lifestyle interventions via education or counselling could be beneficial for COVID outcomes.

We did not find any complex lifestyle intervention aiming to improve outcomes of epidemic respiratory diseases by a comprehensive literature search. It is likely driven by the difficulty of organising clinical trials with lifestyle interventions. Most problems arise from the following circumstances of epidemics; 1 Exceptionally rapid response is required from the healthcare system.

‪Alessandro Mantovani‬ - ‪Google Tudós‬

Unsurprisingly, no randomised clinical trial has been performed, to investigate the effects of a multicomponent preventive lifestyle intervention diabetes mellitus and covid 19 the outcomes of COVID epidemic. Our main objective is to evaluate the effects of a personalised multicomponent lifestyle intervention aiming to improve the outcomes of Diabetes mellitus and covid 19 infection in the population over 60 years in a randomised clinical trial.

Methods Design The study protocol is structured following Spirit [ 24 ]. This design diabetes mellitus and covid 19 interim analyses and necessary modifications of the sample size of the ongoing trial to ensure adequate power [ 25 ]. This Act and Decree would not have allowed commencing the clinical trial as it would have amounted to a criminal offence.

The Steering Committee SC will be led by PH principal investigator, gastroenterologist, a specialist in internal medicine and clinical pharmacology. SC members will be BE gastroenterologist, a specialist in internal medicine and primary careASz interdisciplinary unitZM intensive care specialistand ZH pharmacologist, a specialist in clinical pharmacology.

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There will be independent members as well, and the SC will include a patient representative. The SC will supervise the trial primarily and will make decisions regarding all critical questions e. The sponsor had no role in the design of the trial and will have no access to the randomisation codes or the data. The study will have independent members, including physicians and a safety manager LCto comply with current ethical regulations.

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Data of these subjects will not be recorded; only anonymous feedback will be given. Patients were not included in the recruitment and conduct of the study. Immediately after publications, study results will be disseminated to the population above 60 years of age via the electronic media when, depending on which study arm will better, either general or personal lifestyle intervention will be delivered. Our interventions do not impose a considerable financial burden on patients; therefore, such compensation will not be required.

Volunteering patients, who helped us to test the interventions, claimed that the time and efforts needed to participate in the study and follow the recommendations of the interventions are entirely reasonable and acceptable. Study population Inclusion and exclusion criteria The inclusion criteria of our selective primary prevention programme are as follows: 1 age over 60 years that is, high-risk individuals and 2 informed consent to participate.

  1. Он изменился со времени их последней встречи и прощания в Башне Лоранна, над простиравшейся вокруг пустыней.
  2. Это был мир, не знавший перемен и старения, никогда не освежавшийся дождями и ветрами.
  3. Пойдем, я покажу .
  4. Он проводил очень много времени среди них, наблюдал за их играми и в конце концов был принят ими как друг.

Recruitment The population will be informed about the study and the contact details via social media platforms, newspaper, radio, and television advertisements. Flow and timing A toll-free phone number will be available for all interested diabetes mellitus and covid 19 participation. By dialling this number, the participant will be informed about the trial through a pre-recorded voice message, including the study rationale, conditions of participation, the process of the study, and the information on data protection.

Willing participants will be redirected to an available operator, who will ascertain eligibility. Following verbal consent and randomisation, the operator will obtain key personal information of the participants and all study-related information Fig.

The allocation will not and cannot be concealed from the operator, but it will be concealed from everyone else participants, caregivers, megelőzés és a cukorbetegség kezelésében assessors. The asterisk indicates that the anticipated finishing date is the end of the pandemic or development of the vaccine, but no more than 1 year from the enrolment of the last participant Full size image Interventions Participants will be randomised into two groups: A general health education and B personalised health education.

They will go through questioning and recommendations in 5 domains: 1 mental health, 2 smoking habits, 3 physical activity, 4 dietary habits, and 5 alcohol consumption.

Both groups will receive the same line of questioning to assess habits concerning these domains Suppl. Group A: Questioning will be done in the order as mentioned above, followed by a general health education aiming towards improvement of these factors with general recommendations the expected mean duration is approximately 10 min.

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Group B: Questioning will be done in the same structured order, but an assessment of each domain will be followed by personalised recommendations the expected mean duration is approximately 20 min.

After the first contact, there will be follow-up calls in both groups, with a matching schedule: every week in the first month, every second week in the second month, then monthly.

During these encounters, all change in all five domains since the last call will be assessed. The structure, script, and algorithm of the initial and follow-up lifestyle interventions are detailed in Suppl. The operators have received any healthcare education. Before enrolling participants, the operators have to complete a standard training program consisting of seminars on the interventions held by medical professionals, followed by practice of scenarios.

A kiadvány további cikkei

The operators will be trained not to give additional healthcare advice, and we will not secure other information sources, including electronic and printed material. Since standard delivery of the interventions and diabetes mellitus and covid 19 collection are essential, the first three and every 50th call of each operator will be assessed. Outcomes Based on literature data [ 526 ], the primary endpoint will be defined as the composite of any of the following in COVID cases an accredited laboratory should verify positivitythe rate of: 1.

Secondary endpoints are the following: 1. The number of general practitioner visits 2.

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The number of emergency, hospital, and intensive care admissions 3. The length of hospitalisation and ICU stay 4. The number of organ dysfunctions and failures central nervous system, cardiovascular, respiratory, renal, liver, haematological 5.

Vizsgálatunk célja az volt, hogy megbecsüljük a cukorbetegek ellátására fordított direkt egészségügyi kiadások mértékét annak érdekében, hogy jellemezni tudjuk a betegségterhet ebből a szempontból, illetve, hogy az eredmények hasznosíthatók legyenek további elemzések számára. Cukorbetegként definiáltuk azokat, akik második fél évében orális antidiabetikum- OAD vagy inzulinreceptet váltottak ki. Az így kialakított vizsgálati populációt felosztottuk két csoportra, aszerint, hogy ban részesültek-e aktív fekvőbeteg-ellátásban a cukorbetegség legfontosabb szövődményei miatt.

The measurable lifestyle changes including physical and mental health 6. The costs of care The primary and secondary outcomes will be assessed upon the conclusion of the trial, at least 1 year after the enrolment of the last participant.

Randomisation and blinding Computer-generated random sequence randomisation central will be performed, after giving informed consent. Due to the expected large sample size, we will use simple randomisation. The allocation ratio will be No stratification or blocking will be applied.